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Basic pharmacological approaches

Reviews

Postconditioning and protection from reperfusion injury: where do we stand? Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology
Michel Ovize, Gary F. Baxter, Fabio Di Lisa, Pter Ferdinandy, David Garcia-Dorado, Derek J. Hausenloy, Gerd Heusch, Jakob Vinten-Johansen, Derek M. Yellon, Rainer Schulz

Proteasome inhibition during myocardial infarction
Xichun Yu, David C. Kem

Phosphodiesterase 5 inhibitors: are they cardioprotective?
Thorsten Reffelmann, Robert A. Kloner

Myocardial protection by nitrite
John W. Calvert, David J. Lefer

Orphan targets for reperfusion injury
Javier Inserte, Jos A. Barrabes, Vctor Hernando, David Garcia-Dorado

Original articles

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
John R. Ussher, Wei Wang, Manoj Gandhi, Wendy Keung, Victor Samokhvalov, Tatsujiro Oka, Cory S. Wagg, Jagdip S. Jaswal, Robert A. Harris, Alexander S. Clanachan, Jason R.B. Dyck, Gary D. Lopaschuk

Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats
Yayoi Taniguchi, Naohiko Takahashi, Akira Fukui, Yasuko Nagano-Torigoe, Luong Cong Thuc, Yasushi Teshima, Tetsuji Shinohara, Osamu Wakisaka, Tatsuhiko Ooie, Yukichi Murozono, Kunio Yufu, Mikiko Nakagawa, Masahide Hara, Hironobu Yoshimatsu, Tetsunori Saik

Cardioprotection induced by Na /K -ATPase activation involves extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/Akt pathway
Jin Zheng, Xiuxian Koh, Fei Hua, Guang Li, James W. Larrick, Jin-Song Bian

Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning
Igor Khaliulin, Joanna E. Parker, Andrew P. Halestrap

Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection
Nicolaj Brejnholt Stttrup, Bo Lfgren, Rune Dupont Birkler, Jan Mller Nielsen, Lixing Wang, Christopher Anthony Caldarone, Steen Buus Kristiansen, Hussain Contractor, Mogens Johannsen, Hans Erik Btker, Torsten Toftegaard Nielsen

TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism
Tuanzhu Ha, Yulong Hu, Li Liu, Chen Lu, Julie R. McMullen, Jim Kelley, Race L. Kao, David L. Williams, Xiang Gao, Chuanfu Li

Downregulation of microRNA-29 by antisense inhibitors and a PPAR- agonist protects against myocardial ischaemiareperfusion injury
Yumei Ye, Zhaoyong Hu, Yu Lin, Congfang Zhang, Jose R. Perez-Polo

Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload
Mohamed A. Omar, Lianguo Wang, Alexander S. Clanachan

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
Narasimman Gurusamy, Istvan Lekli, Subhendu Mukherjee, Diptarka Ray, Md. Kaimul Ahsan, Mihaela Gherghiceanu, Lawrence M. Popescu, Dipak K. Das

Arginase inhibition mediates cardioprotection during ischaemiareperfusion
Christian Jung, Adrian T. Gonon, Per-Ove Sjquist, Jon O. Lundberg, John Pernow

Reducing ischaemia/reperfusion injury through -opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signalling
Ming-He Huang, Vincent Nguyen, Yewen Wu, Saurabh Rastogi, Charles Y. Lui, Yochai Birnbaum, Hui-Qun Wang, David L. Ware, Madhu Chauhan, Nisha Garg, Kian-Keong Poh, Lei Ye, Abdul Razakjr Omar, Huay-Cheem Tan, Barry F. Uretsky, Kenichi Fujise

The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury
Zhijuan Cao, Yulong Hu, Wei Wu, Tuanzhu Ha, Jim Kelley, Chenliang Deng, Qi Chen, Chuanfu Li, Jinheng Li, Yuehua Li

MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection
Yanjie Lu, Yong Zhang, Hongli Shan, Zhenwei Pan, Xuelian Li, Baoxin Li, Chaoqian Xu, Bisi Zhang, Fengmin Zhang, Deli Dong, Wuqi Song, Guofen Qiao, Baofeng Yang

Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion
Daniel Chappell, Matthias Jacob, Klaus Hofmann-Kiefer, Markus Rehm, Ulrich Welsch, Peter Conzen, Bernhard F. Becker

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection
Henryk Dreger, Kera Westphal, Andrea Weller, Gert Baumann, Verena Stangl, Silke Meiners, Karl Stangl

Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury
Jennifer L. Strande, Michael E. Widlansky, Nikos E. Tsopanoglou, Jidong Su, JingLi Wang, Anna Hsu, Kasi V. Routhu, John E. Baker

Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemiareperfusion
Ulrich Hofmann, Natalie Burkard, Carolin Vogt, Annemarie Thoma, Stefan Frantz, Georg Ertl, Oliver Ritter, Andreas Bonz

Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1
Pierre Sicard, Sebastien Jacquet, Koichi S. Kobayashi, Richard A. Flavell, Michael S. Marber

Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury
Keiichi Hishikari, Jun-ichi Suzuki, Masahito Ogawa, Kazuya Isobe, Teisuke Takahashi, Michihito Onishi, Kiyoshi Takayama, Mitsuaki Isobe